Polymerase I and Transcript Release Factor (PTRF) (C-Term) Peptide
PTRF
适用: 人
宿主: 合成
BP, WB
Quick Overview for Polymerase I and Transcript Release Factor (PTRF) (C-Term) Peptide (ABIN5511461)
抗原
PTRF
(Polymerase I and Transcript Release Factor (PTRF))
宿主
人
资源
合成
应用范围
Blocking Peptide (BP), Western Blotting (WB)
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蛋白结构域
- C-Term
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序列
- EESRAERIKR SGLRRVDDFK KAFSKEKMEK TKVRTRENLE KTRLKTKENL
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产品特性
- This is a synthetic peptide designed for use in combination with anti-PTRF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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储存条件
- -20 °C
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储存方法
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PTRF (Polymerase I and Transcript Release Factor (PTRF))
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背景
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This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Alias Symbols: PTRF, FKSG13,
Protein Size: 390 -
基因ID
- 284119
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NCBI登录号
- NP_036364
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UniProt
- Q6NZI2
抗原
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